Description

Sitagliptin 50mg is a drug that inhibits the dipeptidyl peptidase-4 (DPP-4). It works by increasing the levels of hormones called incretins, which stimulate insulin release when blood sugar levels are high. Metformin Hydrochloride 1000mg is a biguanide-class drug that helps lower blood glucose levels. It does so by decreasing glucose absorption, improving insulin sensitivity and reducing glucose production by the liver. This medication is insulin-independent, meaning it does not rely on insulin to lower blood sugar. When used in conjunction, Sitagliptin 50mg and Metformin Hydrochloride 1000mg are able to lower serum glucose levels even more effectively than if they are used alone. This is because Sitagliptin increases the concentration of the incretin hormone GLP-1, which stimulates insulin release and decreases the presence of glucagon. Metformin works to lower glucose levels as well, and also enhances GLP-1 signaling, thereby increasing the effects of Sitagliptin. The combination of these mechanisms provides additive glucose lowering effects, making this combination an effective treatment for type-2 diabetes mellitus, helping to manage serum glucose levels.